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VOLUME 1 , ISSUE 1 ( January-April, 2008 ) > List of Articles

RESEARCH ARTICLE

Comparison of Drugs and Intravenous Crystalloid in Reduction of Postoperative Nausea and Vomiting after Laparoscopic Surgery

Alaa H Ali

Citation Information : Ali AH. Comparison of Drugs and Intravenous Crystalloid in Reduction of Postoperative Nausea and Vomiting after Laparoscopic Surgery. World J Lap Surg 2008; 1 (1):29-34.

DOI: 10.5005/jp-journals-10007-1044

Published Online: 01-04-2008

Copyright Statement:  Copyright © 2008; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background

Nausea and vomiting are frequent after general anesthesia, the most important causes of morbidity after anesthesia and surgery are postoperative nausea and vomiting.

Methods

A comparative analysis of published articles was done to determine the relative efficacy and safety of ondansetron, droperidol, metoclopramide, dexamethasone, and intravenous crystalloid fluid for the prevention of postoperative nausea and vomiting. I performed a literature search of English references using both the MEDLINE database and a manual search. Double-blinded, randomized, controlled trials comparing the effect of these agents in reduction or prevention of postoperative nausea and vomiting.

Results

A total of 60 studies were identified, of which 6 were excluded for methodological concerns. For each comparison of drugs, ondansetron (P < 0.001), droperidol (P < 0.001) were more effective than metoclopramide in preventing vomiting. We conclude that ondansetron and droperidol are more effective than metoclopramide in reducing postoperative nausea and vomiting. The incidence of vomiting was reduced in the intravenous administration of crystalloid 30 mg/kg in healthy adults (P = 0.001) and for dexamethasone is (P < 0.03).

Conclusion

In summary, both ondansetron and droperidol were more effective than metoclopramide, intravenous crystalloid fluid and dexamethasone in preventing postoperative vomiting.


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