World Journal of Laparoscopic Surgery

Register      Login

VOLUME 1 , ISSUE 3 ( September-December, 2008 ) > List of Articles

RESEARCH ARTICLE

Laparoscopic Ultrasound–Guided versus Percutaneous Radiofrequency Ablation in Treatment of Unresectable Hepatocellular Carcinoma

Sherif Z Kotb, Tamer F Yousef, Yaser M Foda

Citation Information : Kotb SZ, Yousef TF, Foda YM. Laparoscopic Ultrasound–Guided versus Percutaneous Radiofrequency Ablation in Treatment of Unresectable Hepatocellular Carcinoma. World J Lap Surg 2008; 1 (3):1-12.

DOI: 10.5005/jp-journals-10007-1062

Published Online: 01-12-2008

Copyright Statement:  Copyright © 2008; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objective

The purpose of this study was to compare laparoscopic ultrasound–guided radiofrequency ablation (LUSRFA) versus percutaneous radiofrequency ablation (PRFA) in treatment of localized hepatocellular carcinoma (HCC).

Methods

From January 2005 through April 2008, for 60 consecutive patients, who were diagnosed with localized primary liver cancer and underwent percutaneous RFA (n = 30) or laparoscopic ultrasound guided radiofrequency ablation (n = 30) at our institution. RFA was evaluated prospectively intra- and postoperatively (1, 6, 12, 18 and 24 months after surgery).

Results

Intra and postoperative complications were significantly lower in the LUSRFA group than in the PRFA group. The Hospital stay, intraoperative complications, early and late postoperative complications were significantly reduced with LUSRFA. However, there was insignificant decrease in tumour volume in both groups. Furthermore, Local recurrence and distant metastases in the LUSRFA group showed a significant decrease during follow-up periods.

Conclusion

LUSRFA could be a valuable alternative treatment for selected patients with localized unresectable hepatic malignancies.


PDF Share
  1. Treatment of liver tumours by percutaneous radiofrequency electrocautery. Semin Interv Radiol 1993;2:143-49.
  2. Resection of liver tumors. In Clavien PA, (Ed). Malignant liver tumors. Boston Massachusetts: Blackwell Science 1999;137-49.
  3. An analysis of 412 cases of hepatocellular carcinoma at a Western center. Ann Surg 1999;229:790-99.
  4. Radiofrequency ablation a minimally invasive technique with multiple applications. Cancer J Sci Am 2003;5:356-61.
  5. Transcatheter arterial chemoembolization with or without radiofrequency ablation in the management of patients with advanced hepatic malignancy. Am Surgery 2002;68(9):827-31.
  6. Radiofrequency ablation of hepatic tumors adjacent to the gall bladder: Am J Roentgenol 2003;180:697-701.
  7. Initial experience with laparoscopic radiofrequency ablation of hepatic tumors. Endoscopy 1999;Ed:21,31-318.
  8. Radiofrequency tissue ablation: Increased lesion diameter with a perfusion electrode. Acad Radiol (b) 1996;3:636-44.
  9. Laparoscopic radiofrequency ablation in cirrhotic patients with hepatocellular carcinoma. Ann of Surgical Oncology; Ed 2001;4:67-181.
  10. Radiofrequency interstitial thermal ablation of hepatocellular carcinoma in liver cirrhosis Role of the laparoscopic approach. Surg Endosc 2001;15:141-45.
  11. Complications after radiofrequency of hepatic tumours. Radiology 2003;221(suppl 1):627-33.
  12. Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications. Ann Surg Oncol 2000;7:593-60. [Abstract].
  13. Small hepatocellular carcinoma: treatment with radiofrequency ablation versus ethanol injection. Radiology 2001;210:655-63.
  14. Tumour dissemination after radio-frequency ablation of hepatocellular carcinoma: Hepatology 2003;34:608-09.
  15. Local Recurrences After Intraoperative Radiofrequency Ablation of Liver Metastases: A Comparative Study with Anatomic and Wedge Resections. Annals of Surgical Oncology 2005;11(5):500-05.
  16. A Registry Report of the Impact of Risk Factors on Outcome. Japanese Journal of Clinical Oncology 2007;37(9):658-72.
  17. Surgical resection versus percutaneous radiofrequency thermal ablation in the treatment of hepatocellular carcinoma on cirrhotic liver. Ann Surg 2004;240:102-07.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.