World Journal of Laparoscopic Surgery

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VOLUME 14 , ISSUE 3 ( September-December, 2021 ) > List of Articles


Study of Incidental Carcinoma Gallbladder in Operated Cases of Gallstone Disease at Tertiary Care Hospital in Eastern Uttar Pradesh

Vibhor Jain, Rishu Yogesh Mishra, Megha Gupta, Rahul Omprakash Paliwal

Keywords : Carcinoma, Cholecystectomy, Gallbladder, Incidental, Laparoscopic

Citation Information : Jain V, Mishra RY, Gupta M, Paliwal RO. Study of Incidental Carcinoma Gallbladder in Operated Cases of Gallstone Disease at Tertiary Care Hospital in Eastern Uttar Pradesh. World J Lap Surg 2021; 14 (3):177-182.

DOI: 10.5005/jp-journals-10033-1475

License: CC BY-NC 4.0

Published Online: 05-03-2022

Copyright Statement:  Copyright © 2021; The Author(s).


Background and objectives: Due to the late detection of primary carcinoma of gallbladder (CaGB), the overall prognosis has remained poor with a 5-year survival of 5–10%. In practice, after elective cholecystectomy for presumably benign gallbladder disease, primary CaGB is an unexpected histopathological finding in resected specimens. Current study aims to determine the incidence of incidental CaGB and to determine factors predictive of CaGB in patients operated for chronic cholecystitis. Materials and methods: In this single center, prospective observational study, analysis of incidence and various biological characteristics of 200 consecutive patients with chronic cholecystitis was done who underwent cholecystectomy and were subsequently histologically diagnosed as incidental CaGB. Results of the study were compiled, tabulated, and analyzed using statistical methods, and inference was drawn. Results: In the study, five patients were diagnosed with incidental CaGB histologically after cholecystectomy for chronic cholecystitis, and the incidence of incidental CaGB was 2.5%. Sociodemographic parameters and pathophysiological observations are additionally drawn to determine factors predictive of primary CaGB. Conclusions: In view of the study findings, it may be inferred that chronic cholecystitis is a significant surgical disease in our population. This is significant because laparoscopic cholecystectomy is being more commonly used for the treatment of chronic cholecystitis in which there are considerable chances of perioperative spillage of biliary contents because of which there are possibilities for the very early gallbladder carcinoma becoming a disseminated disease. The operating surgeon should have high index of suspicion regarding this incidental but fatal gastrointestinal malignancy.

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