Aim: This study is aimed to examine the effectiveness of laparoscopic totally extraperitoneal (TEP) repair using three-dimension (3D) mesh to treat bilateral inguinal hernia in adults. Materials and methods: We conducted case series on 50 patients with bilateral inguinal hernias undergoing laparoscopic TEP surgery using 3D mesh at Thanh Nhan Hospital from January 2017 to June 2019. Results: Of 50 patients, 66.0% of patients had a direct inguinal hernia and 34.0% of patients had an indirect inguinal hernia. The diameter of the herniated hole was mainly from 1.5 to 3 cm in 84.0% of patients. There were 82% of patients using small 3D mesh (8.5 × 13.7 cm) and one case required mesh fixation (2.0%). Seven patients (14.0%) had complications during surgery. The average postoperative pain time was 2.2 ± 1.5 days (1–15 days). Pain degree decreased gradually from day 1 to day 3. By day 3 after surgery, 94% of patients had only slight pain, two patients (4.0%) had mild pain, and one patient (2.0%) had moderate pain. All patients were followed for a mean of 21.4 ± 11.8 months (minimum 1 month, maximum 40 months). At 1 month postoperative, there was one patient with chronic pain in the groin (2.1%). After 6, 12, and 24 months, no recurrence was recorded. Conclusion: TEP laparoscopic surgery using 3D mesh is a safe, feasible, and effective method in bilateral inguinal hernia in adults, with low rates of complications and recurrence.