Introduction: Laparoscopic fundoplication is also important after medical management failure of gastroesophageal reflux disease. Nissen's fundoplication effectiveness is widely regarded as safe and effective, with a mortality rate of less than 1%. The purpose of this study is to assess clinical outcomes after laparoscopic Nissen's fundoplication in a patient with hiatus hernia and evaluate postoperative symptom relief, to evaluate postoperative complications, and to evaluate postoperative improvement in patients’ lifestyles. Materials and methodology: This retrospective observational study was conducted in civil hospital Ahmedabad for 30 patients admitted to Civil Hospital, Ahmedabad from May 2019 to October 2021. The selection criteria for cases were based on the physical findings, clinical history, radiological findings, and endoscopic findings. Patient information was collected from the medical record office. Sociodemographic variables include age at diagnosis, marital status, religion, level of education, occupation, and socioeconomic status. Results: In this study, the 51–60 years of age-group is affected mostly and the mean age is 56 years. Females are affected by around 53% as compared with 47% of males. The most common presenting complaint is upper abdominal discomfort followed by heartburn, bloating, and regurgitation. The usual day of discharge is day 3 or 4. Conclusion: Laparoscopic Nissen fundoplication is the better surgery in patients with hiatus hernia with good clinical outcomes. Laparoscopic Nissen fundoplication is an effective surgery for hiatus hernia with minimal complications in expert hands.