Introduction: Colorectal malignancies are one of the most common cancers diagnosed globally. Minimally invasive surgery has gained importance in treating these cancers. However, there is still skepticism with regard to their oncologic outcomes compared to open surgery. With this study, we aim to compare and evaluate both modalities of therapy. Materials and methods: We conducted a prospective, observational study at Kasturba Hospital, Manipal, Karnataka, India between 15 September 2019 and 15 September 2021. A total of 79 patients were recruited in the study and considered in the final analysis, out of which 33 underwent surgery by laparoscopic technique) and 46 underwent surgery by open technique. Both groups were weighed against each other in relation to oncologic outcomes, complications of the surgery, duration of stay in the hospital, cost, and other variables. Results: Both groups were similar with respect to oncologic outcomes, surgical complications, duration of stay in the hospital, and cost. Conclusion: Laparoscopic surgeries are comparable to open surgeries for colorectal cancers with regard to outcome, complications, and cost and should be considered when planning surgery for such malignancies.