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VOLUME 17 , ISSUE 2 ( May-August, 2024 ) > List of Articles


Difficulty in Diagnosing Gastrointestinal Stromal Tumors: Literature Review and Case Report

Mario Pacilli, Alberto Gerundo, Giovanna Pavone, Raffaele De Filippi, Andrea Quazzico, Alberto Fersini, Antonio Ambrosi, Nicola Tartaglia

Keywords : Case report, Diagnostic challenge, Diagnostic laparoscopy, Endoscopic ultrasound, Gastrointestinal stromal tumor, Pancreatic neoplasms

Citation Information : Pacilli M, Gerundo A, Pavone G, De Filippi R, Quazzico A, Fersini A, Ambrosi A, Tartaglia N. Difficulty in Diagnosing Gastrointestinal Stromal Tumors: Literature Review and Case Report. World J Lap Surg 2024; 17 (2):119-125.

DOI: 10.5005/jp-journals-10033-1606

License: CC BY-NC 4.0

Published Online: 18-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors originating primarily from the stomach and small intestine. Preoperative diagnosis of GIST relies on improved computed tomography (CT), endoscopy, and endoscopic ultrasonography (EUS), but despite these tests, there is a high rate of misdiagnosis. The aim of this study was to review the literature focusing on diagnostic methods for such lesions by analyzing preoperative contrast-enhanced CT, endoscopy, EUS, and other tests. Materials and methods: A systematic search of articles using electronic databases (MEDLINE, and Embase) was conducted in the last 10 years and 106 items were filtered from the search list. Finally, we report our experience of “difficult diagnosis” in which several diagnostic methods were needed and a definitive diagnosis could only be made after surgical resection. Results: After a review of all papers, 95 studies were excluded, due to incorrect study design, wrong population, non-English language, or other reasons. Finally, 41 studies were included, with a total of 2860 analysis cases. Conclusions Difficult diagnosis when dealing with GIST is particularly notable. Our study emphasizes how the need to reach the correct diagnosis may lead to performing countless preoperative examinations without arriving at the goal. Our case presentation reports a GIST mimicking pancreatic cyst.

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