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VOLUME 8 , ISSUE 1 ( January-April, 2015 ) > List of Articles


Difference between the Inflammatory Reaction Caused by the Placement of a Conventional Laparoscopic Access and a Single Access (Single Port) in Pigs

Ricardo Jordão Duarte, Rodolfo Anísio Santana Torres Bandeira, Angelo Vattimo, Sabrina Thalita dos Reis, Kátia Ramos Moreira Leite, Lilian Maria Cristofani, Miguel Srougi

Citation Information : Duarte RJ, Bandeira RA, Vattimo A, Reis ST, Leite KR, Cristofani LM, Srougi M. Difference between the Inflammatory Reaction Caused by the Placement of a Conventional Laparoscopic Access and a Single Access (Single Port) in Pigs. World J Lap Surg 2015; 8 (1):1-6.

DOI: 10.5005/jp-journals-10033-1236

Published Online: 01-06-2010

Copyright Statement:  Copyright © 2015; The Author(s).



To compare the acute inflammatory responses of CL and SA, considering only the trauma caused by the placement of the access port, at first time without pneumoperitoneum or other surgical manipulation. The variations of serum interleukin (IL)-4, -6, -8 and -10, tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP) were evaluated.

Materials and methods

Twenty pigs were randomly divided into two groups: a SA group and a CL group. In the SA group, the procedure began with a 2.5 cm skin incision, aponeurosis and peritoneum, and then the single-access device (Gelport®) was placed without pneumoperitoneum. In the CL group, the incision was performed on the skin, aponeurosis and peritoneum, and the four trocars were placed only with the traction of the abdominal wall. Once the access points were placed, blood samples were collected to measure the cytokines and CRP at: time zero (T0), immediately after anesthesia (including intubation); T1, immediately after the access point(s) was placed; T2, 120 minutes after the access point(s) was placed; and T3, 240 minutes after the access point(s) was placed.


The concentrations of IL-4 and TNF-α decreased between T0 and T3. IL-10 and CRP also decreased, but not significantly. IL-6 and IL-8 increased, but not significantly.


During the study, there was no significant difference between the inflammatory response triggered exclusively by placing the SA and CL without pneumoperitoneum.

How to cite this article

Duarte RJ, Bandeira RAST, Vattimo A, dos Reis ST, Leite KRM, Cristofani LM, Srougi M. Difference between the Inflammatory Reaction Caused by the Placement of a Conventional Laparoscopic Access and a Single Access (Single Port) in Pigs. World J Lap Surg 2015;8(1):1-6.

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