World Journal of Laparoscopic Surgery

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VOLUME 9 , ISSUE 1 ( January-April, 2016 ) > List of Articles

RESEARCH ARTICLE

The Effect of Tranexamic Acid on Blood Loss during Laparoscopic Sleeve Gastrectomy

Citation Information : The Effect of Tranexamic Acid on Blood Loss during Laparoscopic Sleeve Gastrectomy. World J Lap Surg 2016; 9 (1):30-33.

DOI: 10.5005/jp-journals-10033-1266

Published Online: 01-04-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background

Tranexamic acid (TXA) is an antifibrinolytic drug that has the property to reduce intraoperative and postoperative bleeding. This study was intended to establish the effect of TXA in minimizing the intraoperative and postoperative blood loss in laparoscopic sleeve gastrectomy.

Materials and methods

This was a prospective follow-up study conducted in Sabah Hospital, Kuwait, over 4 months from September 2014 to December 2014. A total of 50 patients who underwent laparoscopic sleeve gastrectomy were included in this study; 25 patients were given tranexamic acid during induction and 25 did not receive. Selection of patients was done on a random basis. Intraoperative blood loss, visibility of field of surgery, and amount of blood collected in suction apparatus used during surgery.

Results

Each group consisted of 25 patients. Preoperative intravenous bolus administration of TXA at 10 mg/kg reduces blood loss.

Conclusion

Tranexamic acid is an antifibrinolytic agent that inhibits the action of plasmin. There is also reduction in blood level of D-dimer. It is seen to significantly reduce intraoperative blood loss during surgery. Additionally, there seems to be no alterations of coagulation parameters or untoward systemic effects. This should prompt further trials.

How to cite this article

Alhomoud H. The Effect of Tranexamic Acid on Blood Loss during Laparoscopic Sleeve Gastrectomy. World J Lap Surg 2016;9(1):30-33.


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