Aim and objective: Spasmo-proxyvon addiction-induced gastric complication has been sparsely discussed in the literature. This study highlights the laparoscopic management of gastric outlet obstruction secondary to spasmo-proxyvon abuse. Materials and methods: From January 2015 to May 2020, 16 patients presenting with gastric outlet obstruction due to spasmo-proxyvon addiction were managed with laparoscopic truncal vagotomy and gastrojejunostomy. Preoperative data, immediate outcome, and long-term results were analyzed. Results: All the 16 patients managed with laparoscopic truncal vagotomy and antecolic posterior gastrojejunostomy were male patients. Median age was 36.5 years and median duration of addiction was 25.5 months. The mean operative time was 139.30 minutes. There was no conversion to laparotomy. There was no intra and immediate postoperative mortality. Two patients had delayed gastric emptying in the immediate postoperative period. Median follow-up was 37.30 months. All the patients had significant improvement in oral intake and weight gain. One patient died due to severe anorexia, malnutrition, and generalized anasarca secondary to resumption of drug abuse one year after surgery. Conclusion: Laparoscopic truncal vagotomy and gastrojejunostomy is a useful mean to manage gastric outlet obstruction secondary to spasmo-proxyvon addiction. This method results in satisfactory perioperative and optimal long-term outcome.