World Journal of Laparoscopic Surgery

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VOLUME 15 , ISSUE 3 ( September-December, 2022 ) > List of Articles

RESEARCH ARTICLE

The Prevalence of Malignant Tumors of the Appendix in Patients with a History of Appendectomy and its Association with Demographic and Laboratory Variables

Behnam Reza Makhsosi, Fatemeh Darabi, Tara Mazaheri, Mansour Rezaei, Zohair Mazaheri, Alireza Rohban

Keywords : Appendicitis, Appendectomy, Iran, Tumors

Citation Information : Makhsosi BR, Darabi F, Mazaheri T, Rezaei M, Mazaheri Z, Rohban A. The Prevalence of Malignant Tumors of the Appendix in Patients with a History of Appendectomy and its Association with Demographic and Laboratory Variables. World J Lap Surg 2022; 15 (3):235-238.

DOI: 10.5005/jp-journals-10033-1530

License: CC BY-NC 4.0

Published Online: 08-12-2022

Copyright Statement:  Copyright © 2022; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: Appendicitis is one of the major causes of acute abdominal pain and one of the most common reasons for emergency surgery. Studies have shown that those that have undergone appendectomy are more likely to develop malignant tumors of the appendix. The present study investigates the prevalence of the appendix's malignant tumors in patients with a history of appendectomy and its association with demographic and laboratory variables. Materials and methods: This study is descriptive, in which 4940 patients with a history of appendectomy between 2011 and 2018 in Imam Reza Hospital, Kermanshah, Iran, have been studied. Initially, the patients’ medical files were investigated, and the necessary demographic and laboratory information were extracted. Then, the data were analyzed by descriptive statistics, including mean and variance for quantitative variables and frequency/percentage plus two-dimensional contingency tables for qualitative variables by SPSS 21. Results: The mean age of the patients with appendectomy was 25.50 years, and the prevalence of malignant tumors of the appendix in patients was 0.5%. Overall, 41 cases (0.8%) showed positive pathology regarding the existence of a tumor in the appendix; among them, 26 cases (0.5%) had malignant types, while 15 cases (0.3%) showed benign types. Out of the 26 cases with the appendix's malignant tumors, 14 were male (53.8%), and 12 were female (46.2%). The majority of malignant tumors of the appendix were observed in those above 50 years of age. Among the malignant tumors, 9 (34.61%) were adenocarcinoma mucinous, 6 (23.07%) were carcinoid, 5 (19.23%) were adenocarcinoma, 5 (19.23%) were malignant mucocele, and 1 (3.84%) was cystadenoma. The relationship between the number of white blood cells (WBC) and the appendix's malignant tumors was significant; the WBC count was significantly lower in those with malignant tumors compared to others. In addition, the relationship between age and the existence of malignant tumors was significant (p = 0.025); older individuals were significantly more likely to develop malignant tumors of the appendix compared with younger individuals. The study results did not show any significant relationship between gender and the presence of malignant tumors of the appendix (p = 0.340). Conclusion: Concerning the local invasion and distant metastasis of some appendix tumors, follow-up of pathology reports by the patient (especially older ones) as well as the physician plus post-appendectomy checkup within short and regular time intervals and, if required, follow-up treatment is essential.


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