World Journal of Laparoscopic Surgery

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VOLUME 17 , ISSUE 2 ( May-August, 2024 ) > List of Articles

Original Article

A Prospective Randomized Study to Evaluate if Cyanoacrylate Glue is Superior over Traditional Suturing in Laparoscopic Port Site Skin Closure

Darshan R Gandhi, Girish Kullolli, Tejaswini Vallabha, Vikram U Sindgikar, Ramakanth S Baloorkar

Keywords : Adhesive glues, Laparoscopic port site skin closure, Southampton scoring system, Surgical site infection, Visual analog scale

Citation Information : Gandhi DR, Kullolli G, Vallabha T, Sindgikar VU, Baloorkar RS. A Prospective Randomized Study to Evaluate if Cyanoacrylate Glue is Superior over Traditional Suturing in Laparoscopic Port Site Skin Closure. World J Lap Surg 2024; 17 (2):103-107.

DOI: 10.5005/jp-journals-10033-1618

License: CC BY-NC 4.0

Published Online: 18-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Background: This study was undertaken to evaluate if the cyanoacrylate glue was superior to conventional suturing for skin closure of the laparoscopic port site. Materials and methods: A prospective randomized trial was performed on patients scheduled for elective laparoscopic surgery at the department of general surgery at a tertiary care hospital. Patients were followed up to evaluate postoperative pain using the visual analog scale (VAS). The time required for closing the wound, postoperative pain at the wound site, rate of surgical site infection (SSI), and the period for which the patients stayed in the hospital were studied. Results: A total of 70 patients were enrolled and divided into two groups. In group I (the study group) incisions were closed by applying N-Butyl-2-Cyanoacrylate glue and in group II (the control group) incisions were closed by conventional suturing method using Ethilon 2.0 RC. Statistically significant difference was found between the average time required for the closure of a single port site (p < 0.0001), surgical site infection (p < 0.021), and the average number of days the patient stayed in the hospital. It was less in the group I as compared with that of group II. There was no significant difference between the two groups for postoperative pain assessment. Conclusion: The use of N-Butyl-2-Cyanoacrylate at laparoscopic port site skin closure was beneficial as it took comparatively less time for laparoscopic port skin closure and had less rate of surgical site infection at the wound site.

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  1. Garg S, Dahiya N, Gupta S. Surgical scar revision: An overview. J Cutan Aesthet Surg 2014;7(1):3–13. DOI: 10.4103/0974-2077.129959.
  2. Coover HW, Dreifus DW, O'connor JT. Cyanoacrylate adhesives. In: Skeist I (editor), Handbook of Adhesives Boston, MA: Springer; 1990, pp. 463–477.
  3. Simon B, Hern HG. Wound management principles. In: Marx J, Hockbergr R, Walls R, editors, Rosen's Emergency Medicine, 8th edition. Philadelphia: Saunders; 2014, pp. 751–766.
  4. Langley GB, Sheppeard H. The visual analogue scale: Its use in pain measurement. Rheumatol Int 1985;5(4):145–148. DOI: 10.1007/BF00541514.
  5. Knop C, Oeser M, Bastian L, et al. Development and validation of the visual analogue scale (VAS) spine score. Unfallchirurg 2001;104(6):488–497. DOI: 10.1007/s001130170111.
  6. Campwala I, Unsell K, Gupta S. A comparative analysis of surgical wound infection methods: predictive values of the CDC, ASEPSIS, and Southampton scoring systems in evaluating breast reconstruction surgical site infections. Plast Surg (Oakv) 2019;27(2):93–99. DOI: 10.1177/2292550319826095.
  7. De Melo WM, Maximiano WM, Antunes AA, et al. Cytotoxicity testing of methyl and ethyl 2-cyanoacrylate using direct contact assay on osteoblast cell cultures. J Oral Maxillofac Surg 2013;71(1):35–41. DOI: 10.1016/j.joms.2012.09.002.
  8. Surena F Matin. Prospective randomized trial of skin adhesive versus sutures for closure of 217 laparoscopic port-site incisions. J Am Coll Surg 2003;196(6):845–853. DOI: 10.1016/s1072-7515(03)00119-4.
  9. Mertz PM, Davis SC, Cazzaniga AL, et al. Barrier and antibacterial properties of 2-octyl cyanoacrylate-derived wound treatment films. J Cutan Med Surg 2003;7(1):1–6. DOI: 10.1007/s10227-002-1154-6.
  10. Sharma T, Kaul N, Kumar A, et al. A randomized controlled study of port site closure using 2-octyl cyanoacrylate versus conventional suturing, post laparoscopic cholecystectomy. JK Pract 2021;26(1): 19–23. Available from:
  11. Maniar N, Deshpande AA. A randomized controlled trial of tissue adhesive versus sutures in the closure of port-site incisions in laparoscopic surgery. IOSR J Dent Med Sci 2016;15(8):66–70. DOI: 10.9790/0853-1508056670.
  12. Sebesta MJ, Bishoff JT. Octylcyanoacrylate skin closure in laparoscopy. J Endourol 2003;17(10):899–903. DOI: 10.1089/089277903772036235.
  13. Quinn JV, Drzewiecki A, Li MM, et al. A randomized, controlled trial comparing a tissue adhesive with suturing in the repair of pediatric facial lacerations. Ann Emerg Med 1993;22(7):1130–1135. DOI: 10.1016/s0196-0644(05)80977-1.
  14. National Institute for Health and Care Research (NIHR). Journals Library. Cochrane Programme Grants. Available at: Accessed on: 2 November 2022.
  15. Dowson CC, Gilliam AD, Speake WJ, et al. A prospective, randomized controlled trial comparing n-butyl cyanoacrylate tissue adhesive (LiquiBand) with sutures for skin closure after laparoscopic general surgical procedures. Surg Laparosc Endosc Percutan Tech 2006;16(3):146–150. DOI: 10.1097/00129689-200606000-00005.
  16. Safta YB, Maatouk M, Bouzidi MT, et al. A randomised clinical trial to compare octyl cyanoacrylate with absorbable monofilament sutures for the closure of laparoscopic cholecystectomy port incisions. Int Wound J 2020;17(2):449–454. DOI: 10.1111/iwj.13294.
  17. Aitchison LP, Chen AZ, Toms C, et al. To stitch or not to stitch: The skin closure of laparoscopic port sites, a meta-analysis. Surg Endosc 2022;36(10):1–20. DOI: 10.1007/s00464-022-09269-9.
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