Citation Information :
Bhandari M, Bhel S, Kosta S, Mathur W, Bhandari M, Neto MG. Nonsurgical Approaches to Weight Loss and Diabetes Remission: A Comprehensive Study of the Swallowable Balloon Intervention. World J Lap Surg 2025; 18 (1):34-37.
Introduction: Obesity and type 2 diabetes mellitus (T2DM) pose significant health challenges, necessitating innovative interventions. This study aims to explore the efficacy of a novel swallowable balloon process in addressing these dual burdens.
Methodology: To evaluate weight loss, diabetes remission, and adverse events (AEs) in 150 patients with a body mass index of 30–40 kg/m2. The swallow balloon was inserted, and outcomes were assessed over a 6-month follow-up period.
Results: The swallowable balloon process demonstrated consistent and significant (p < 0.001) weight loss, with mean percentage total weight loss (%TWL) ranging from 6.8 to 14.6% and mean percentage excess weight loss (% EWL) ranging from 15.5 to 32.8% over the 6-month follow-up period. Remarkably, diabetes remission rates were notable at 30% in 3 months and an impressive 67% in 6 months post-balloon insertion. However, AEs, particularly nausea and vomiting extending beyond one week, occurred in 12% of participants, leading to hospital admission, highlighting the importance of careful monitoring and management. Additionally, nausea and vomiting occurred in 46.6% and 40.6% of participants, respectively, without major complications.
Conclusion: The swallowable balloon process demonstrates promising outcomes in weight loss and diabetes remission over the end of period. AEs require careful consideration, emphasizing the need for ongoing research to optimize safety and efficacy. This intervention offers a nonsurgical approach for individuals with obesity and T2DM, marking a significant step toward addressing these interconnected health challenges.
Ruze R, Liu T, Zou X, et al. Obesity and type 2 diabetes mellitus: Connections in epidemiology, pathogenesis, and treatments. Front Endocrinol (Lausanne) 2023;14:1161521. DOI: 10.3389/fendo.2023.1161521.
Hecker J, Freije, K, Hiligsmann M, et al. Burden of disease study of overweight and obesity; the societal impact in terms of cost-of-illness and health-related quality of life. BMC Public Health 2022;22:46. DOI: 10.1186/s12889-021-12449-2.
World Health Organization. Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000;894(i–xii):1–253. PMID: 11234459.
Wadden TA, Tronieri JS, Butryn ML. Lifestyle modification approaches for the treatment of obesity in adults. Am Psychol 2020;75(2):235–251. DOI: 10.1037/amp0000517.
Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32(1):193–203. DOI: 10.2337/dc08-9025.
Haddad F, Dokmak G, Bader M, et al. A comprehensive review on weight loss associated with anti-diabetic medications. Life (Basel) 2023;13(4):1012. DOI: 10.3390/life13041012.
Apovian CM, Okemah J, O'Neil PM. Body weight considerations in the management of type 2 diabetes. Adv Ther 2019;36:44–58. DOI: 10.1007/s12325-018-0824-8.
Bhandari M, Neto MG, Kosta S, et al. Emerging outcomes for treatment of obesity with Type 2 diabetes mellitus: Novel swallowable balloon process. J Obes Weight Loss Ther 2022;12:535. DOI: 10.4172/2165-7904.1000535.
Genco A, Ernesti I, Ienca R, et al. Safety and efficacy of a new swallowable intragastric balloon not needing endoscopy: Early Italian experience. Obes Surg 2018;28:405–409. DOI: 10.1007/s11695-017-2877-1.
Al-Subaie S, Khalifa S, Buhaimed W, et al. A prospective pilot study of the efficacy and safety of Elipse intragastric balloon: A single-center, single-surgeon experience. Int J Surg 2017;48:16–22. DOI: 10.1016/j.ijsu.2017.10.001.
Raftopoulos I, Giannakou A. The elipse balloon, a swallowable gastric balloon for weight loss not requiring sedation, anesthesia or endoscopy: A pilot study with 12-month outcomes. Surg Obes Relat Dis 2017;13:1174–1182. DOI: 10.1016/j.soard.2017.02.016.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33:S62–S69. DOI: 10.2337/dc10-S062.