World Journal of Laparoscopic Surgery

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VOLUME 1 , ISSUE 3 ( September-December, 2008 ) > List of Articles


Laparoscopic Ultrasound–Guided versus Percutaneous Radiofrequency Ablation in Treatment of Unresectable Hepatocellular Carcinoma

Sherif Z Kotb, Tamer F Yousef, Yaser M Foda

Citation Information : Kotb SZ, Yousef TF, Foda YM. Laparoscopic Ultrasound–Guided versus Percutaneous Radiofrequency Ablation in Treatment of Unresectable Hepatocellular Carcinoma. World J Lap Surg 2008; 1 (3):1-12.

DOI: 10.5005/jp-journals-10007-1062

Published Online: 01-12-2010

Copyright Statement:  Copyright © 2008; The Author(s).



The purpose of this study was to compare laparoscopic ultrasound–guided radiofrequency ablation (LUSRFA) versus percutaneous radiofrequency ablation (PRFA) in treatment of localized hepatocellular carcinoma (HCC).


From January 2005 through April 2008, for 60 consecutive patients, who were diagnosed with localized primary liver cancer and underwent percutaneous RFA (n = 30) or laparoscopic ultrasound guided radiofrequency ablation (n = 30) at our institution. RFA was evaluated prospectively intra- and postoperatively (1, 6, 12, 18 and 24 months after surgery).


Intra and postoperative complications were significantly lower in the LUSRFA group than in the PRFA group. The Hospital stay, intraoperative complications, early and late postoperative complications were significantly reduced with LUSRFA. However, there was insignificant decrease in tumour volume in both groups. Furthermore, Local recurrence and distant metastases in the LUSRFA group showed a significant decrease during follow-up periods.


LUSRFA could be a valuable alternative treatment for selected patients with localized unresectable hepatic malignancies.

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