Laparoscopic sleeve gastrectomy (LSG) is being performed more frequently and is currently very “trendy” among laparoscopic surgeons involved in bariatric surgery. Laparoscopic sleeve gastrectomy is associated with a marked reduction of ghrelin secretion, which is produced by the gastric fundus involved in mealtime hunger regulation, and it is also known to extend several diabetogenic effects.
The aim of this study is to assess the short- and long-term effects of LSG on body weight and glucose homeostasis in morbidly obese diabetic patients.
Materials and methods
This is a prospective study that was conducted on 40 diabetic patients randomly selected suffering from morbid obesity that had type II diabetes mellitus (T2DM). Patients were managed by LSG in AL-Zahraa Hospital, Faculty of Medicine for girls, Al-Azhar University, from January 2012 to December 2015, to assess the short- and long-term effects of the procedure on glucose homeostasis.
The study was conducted on 40 patients of morbid obesity that had T2DM. The preoperative mean fasting blood glucose (FBG) level was 209.3 ± 36.6 (156–299) mg/dL and postoperatively was 172.5 ± 29 (130–250) mg/dL, 125.6 ± 16.7 (99–169) mg/dL, 111.7 ± 20.9 (77–167) mg/dL, 105 ± 18.3 (73–137) mg/dL, and 102.9 ± 21 (70–145) mg/dL at 1 day and 3, 6, 9, and 12 months respectively. Postoperatively, the FBG levels were improved with significant declining at 1 day (p < 0.001), 3 months (p < 0.001), and 6 months (p < 0.004) but nonsignificant declining at 9 months (p < 0.25) and 12 months (p = 1).
Laparoscopic sleeve gastrectomy is an effective surgical treatment for most severely or morbidly obese patients with DM. Weight loss is effective treatment for patients with these medical problems. The SG is associated with a high rate of resolution of T2DM at 12 months after surgery in severely obese patients with T2DM.
How to cite this article
Abdelmohsen M, Badr H. Short- and Long-term Effects of Laparoscopic Sleeve Gastrectomy on Body Weight and Glucose Homeostasis in Diabetic Patients. World J Lap Surg 2017;10(2):45-50.